I completed where I left off previously. Died once and almost twice as I was running out of oxygen. I picked up a new weapon type called "Spike", which I assume is some kind of rocket launcher(?).... maybe.
Alright! It was tough as I had a hunter alien on my heels the whole time, but I was able to reach Nicole, who was attached to the Marker. I defeated her (eventually) and made my escape with Ellie. What a cool game. Final boss and game ending! Great stream!