I had some issues with one particular warchief. Killed repeatedly by the hound type of monsters. Still, I was lucky enough to prevail. Now following the main quest storyline but also paying attention to the secondary quests. My armor and weapons are maxed out for my character level.. I just wished the focus shots would last longer.
Alright! It was tough as I had a hunter alien on my heels the whole time, but I was able to reach Nicole, who was attached to the Marker. I defeated her (eventually) and made my escape with Ellie. What a cool game. Final boss and game ending! Great stream!